If you are an adult who has struggled to lower your blood Phe levels, PALYNZIQ™ (pegvaliase-pqpz) Injection may be the treatment you have been waiting for.
PALYNZIQ is used to lower phenylalanine (Phe) levels in adults with PKU who have uncontrolled blood Phe above 600 micromol/L (10 mg/dL) with existing management.
Start getting your Phe under control
PALYNZIQ has been proven to significantly lower Phe
* Results from a study of patients who had previously achieved a reduction in Phe levels of 20% or more with PALYNZIQ 20 mg once daily.
Contact your healthcare provider right away if you have any of the following symptoms of an allergic reaction including: rash, itching, or swelling of the face, lips, eyes, or tongue. Your healthcare provider may change your dose of PALYNZIQ, stop treatment for a period of time, or prescribe medicine for you to take before your PALYNZIQ injection to help reduce the symptoms of an allergic reaction.
Keep your levels on target
PKU experts recommend that people with PKU maintain Phe levels between 120—360 micromol/L (2–6 mg/dL) throughout their lives.
It can take time to find the dose that works best for you.
You may need to reach a PALYNZIQ dose of 20 mg or 40 mg once daily before you can achieve your target Phe level. Work with your healthcare provider to find the lowest dose that works for you.
Remember, it can take time to find the right dose—and may take longer than 8 months.
Your healthcare provider will monitor your diet throughout treatment with PALYNZIQ and counsel you on how to adjust your diet as needed, based on Phe levels.
Understanding side effects
Your body may recognize PALYNZIQ as foreign, which can cause side effects, including anaphylaxis, which may be serious.
- In clinical studies, nearly all patients taking PALYNZIQ experienced a side effect. Your healthcare provider will discuss these risks with you before you start taking PALYNZIQ
- Some people (9%) taking PALYNZIQ had anaphylaxis, which is a potentially life-threatening reaction
Anaphylaxis is a type of severe allergic reaction
It’s important to be aware of the signs and symptoms of this type of reaction.
- Fainting (passing out)
- Dizziness or lightheadedness
- Sudden confusion
- Trouble breathing or wheezing
- Chest discomfort or chest tightness
- Fast heart rate
- Swelling of your face, lips, eyes, or tongue
- Throat tightness
- Flushed skin
- Skin rash, itching, or raised bumps on skin
- Nausea, vomiting, or diarrhea
- Losing control of urine or stools
Your healthcare provider will educate you on what signs to watch for and what to do if you have anaphylaxis.
For your safety, your healthcare provider will prescribe auto-injectable epinephrine. Carry the auto-injectable epinephrine with you at all times during treatment with PALYNZIQ.
Common side effects
In clinical studies, most side effects with PALYNZIQ were considered to be mild to moderate, and generally decreased over time. Side effects may occur at any time during treatment.
Here are some of the side effects associated with PALYNZIQ:
About joint pain
Although most people taking PALYNZIQ experienced some form of joint pain, it went away in 2 weeks on average.